Roles > EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor
Page last updated: 2024-08-05 15:26:47

EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor

An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of enoyl-[acyl-carrier-protein] reductase (NADH), EC 1.3.1.9.

ChEBI ID: 139512

Members (2)

MemberDefinitionClass
atromentinA member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione which is substituted by a 4-hydroxyphenyl group at positions 3 and 6. It is a mushroom pigment isolated from several fungi species and acts as a smooth muscle stimulant, and exhibits anticoagulant, antibacterial and antineoplastic properties.atromentin
triclosanAn aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.triclosan

Research

Studies (3,272)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990521 (15.92)18.7374
1990's200 (6.11)18.2507
2000's655 (20.02)29.6817
2010's1,370 (41.87)24.3611
2020's526 (16.08)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials379 (11.20%)5.53%
Reviews176 (5.20%)6.00%
Case Studies24 (0.71%)4.05%
Observational7 (0.21%)0.25%
Other2,799 (82.69%)84.16%

Protein Targets (98)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency7.943311
acetylcholinesteraseHomo sapiens (human)Potency39.097423
activating transcription factor 6Homo sapiens (human)Potency52.503122
Alpha-synucleinHomo sapiens (human)Potency11.220211
AR proteinHomo sapiens (human)Potency22.2234810
aryl hydrocarbon receptorHomo sapiens (human)Potency47.850722
Ataxin-2Homo sapiens (human)Potency8.837311
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency8.837311
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency55.759511
caspase-3Cricetulus griseus (Chinese hamster)Potency62.563211
caspase-3Homo sapiens (human)Potency55.759511
Caspase-7Cricetulus griseus (Chinese hamster)Potency62.563211
Cellular tumor antigen p53Homo sapiens (human)Potency50.140633
Chain A, Ferritin light chainEquus caballus (horse)Potency35.481311
cytochrome P450 2C9, partialHomo sapiens (human)Potency3.473012
cytochrome P450 2D6Homo sapiens (human)Potency8.370212
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency18.738612
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency17.632711
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency63.095711
estrogen nuclear receptor alphaHomo sapiens (human)Potency41.69151012
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency65.652833
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency22.42651015
farnesoid X nuclear receptorHomo sapiens (human)Potency33.355445
Fumarate hydrataseHomo sapiens (human)Potency63.095711
GVesicular stomatitis virusPotency3.473012
gemininHomo sapiens (human)Potency16.754312
GLI family zinc finger 3Homo sapiens (human)Potency32.266736
glp-1 receptor, partialHomo sapiens (human)Potency28.183811
GLS proteinHomo sapiens (human)Potency35.481311
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency28.804034
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency27.844912
heat shock protein beta-1Homo sapiens (human)Potency34.665024
Histone H2A.xCricetulus griseus (Chinese hamster)Potency51.710211
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency3.473012
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency40.691323
IDH1Homo sapiens (human)Potency23.109311
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency3.473014
Interferon betaHomo sapiens (human)Potency18.831023
lamin isoform A-delta10Homo sapiens (human)Potency0.031611
Microtubule-associated protein tauHomo sapiens (human)Potency0.199511
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency29.402435
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency34.559422
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency46.415333
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency35.481311
ParkinHomo sapiens (human)Potency28.183811
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency32.856034
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency48.642433
PINK1Homo sapiens (human)Potency28.183811
polyproteinZika virusPotency63.095711
pregnane X nuclear receptorHomo sapiens (human)Potency22.954212
progesterone receptorHomo sapiens (human)Potency28.332224
RAR-related orphan receptor gammaMus musculus (house mouse)Potency22.589624
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency28.381436
retinoid X nuclear receptor alphaHomo sapiens (human)Potency26.364333
SMAD family member 2Homo sapiens (human)Potency59.664922
SMAD family member 3Homo sapiens (human)Potency59.664922
Smad3Homo sapiens (human)Potency17.782811
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency10.000011
TAR DNA-binding protein 43Homo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency19.898026
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency19.913535
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency44.668411
thyroid stimulating hormone receptorHomo sapiens (human)Potency49.695711
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency33.188622
USP1 protein, partialHomo sapiens (human)Potency39.810711
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency27.874524
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency39.565922
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency27.844912
VprHuman immunodeficiency virus 1Potency56.234111

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
3-oxoacyl-[acyl-carrier-protein] synthase 3 Escherichia coliIC50850.000011
Carbonyl reductase [NADPH] 1Homo sapiens (human)IC500.400011
Carbonyl reductase [NADPH] 1Homo sapiens (human)Ki0.060011
Chain A, enoyl-acyl carrier reductasePlasmodium falciparum (malaria parasite P. falciparum)Ki0.050013
Chain C, enoyl-acyl carrier reductasePlasmodium falciparum (malaria parasite P. falciparum)Ki0.050013
DNA gyrase subunit AEscherichia coli K-12IC501,000.000011
DNA gyrase subunit BEscherichia coli K-12IC501,000.000011
Endoplasmic reticulum chaperone BiPHomo sapiens (human)IC50100.000011
Enoyl-[acyl-carrier-protein] reductase [NADH]Mycobacterium tuberculosis H37RvIC502.871288
Enoyl-[acyl-carrier-protein] reductase [NADH]Mycobacterium tuberculosis H37RvKi0.210044
Enoyl-[acyl-carrier-protein] reductase [NADH] Francisella tularensis subsp. tularensis SCHU S4IC504.330055
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIBacillus subtilis subsp. subtilis str. 168IC500.500011
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIEscherichia coli K-12IC502.9579812
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIHaemophilus influenzae Rd KW20IC507.642524
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabIStaphylococcus aureus subsp. aureus MRSA252IC502.60491014
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabIStaphylococcus aureus subsp. aureus MRSA252Ki0.000011
Enoyl-ACP reductase II Streptococcus pneumoniaeIC5032.000022
Enoyl-acyl carrier reductaseToxoplasma gondiiIC500.016733
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)IC500.087288
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)Ki0.05541717
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC500.585022
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC5075.000011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC5075.000011
Sentrin-specific protease 1Homo sapiens (human)IC504.945022
TransthyretinHomo sapiens (human)IC5053.500011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, RepressorStenotrophomonas maltophiliaKd0.630011
TransthyretinHomo sapiens (human)Kd144.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
heat shock protein 90, putativePlasmodium falciparum 3D7AC507.544011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)AC507.847011
twin arginine protein translocation system - TatA proteinEscherichia coli str. K-12 substr. MG1655AC501.060011